Cafergot 1 mg/100 mg: Uses, Dosage, Side Effects, Safety, and Frequently Asked Questions
Learn about Cafergot 1 mg/100 mg, including its medical uses, dosage considerations, side effects, precautions, drug interactions, and important safety information. Educational content only.
Cafergot 1 mg/100 mg: Everything You Need to Know
Cafergot 1 mg/100 mg is a prescription medication that combines ergotamine tartrate (1 mg) and caffeine (100 mg). It is primarily used to treat certain Migraine attacks after symptoms begin. It is not intended to prevent migraines or to treat other types of headaches, such as tension headaches.
Ergotamine works by narrowing widened blood vessels involved in migraine attacks, while caffeine helps improve the absorption and effectiveness of ergotamine. Because this medication has important safety considerations and potential interactions, it should only be used under the guidance of a qualified healthcare professional.
This guide explains what Cafergot is, how it works, its approved uses, possible side effects, safety precautions, and answers to frequently asked questions.
What Is Cafergot 1 mg/100 mg?

Cafergot is a combination prescription medication containing:
- Ergotamine tartrate (1 mg) – an ergot alkaloid that helps relieve migraine symptoms by constricting certain blood vessels.
- Caffeine (100 mg) – a stimulant that enhances the absorption and effectiveness of ergotamine.
Cafergot is intended for the treatment of migraine attacks after they begin. It should be used according to the prescribing information and under medical supervision.
Approved Medical Uses
Healthcare providers may prescribe Cafergot for:
- Treatment of migraine attacks with or without aura
- Relief of migraine symptoms after onset
Cafergot is not recommended for:
- Preventing migraines
- Treating cluster headaches unless specifically directed by a specialist
- Treating ordinary tension headaches
- Chronic daily headache management
How Does Cafergot Work?
During a migraine attack, certain blood vessels around the brain may become enlarged and inflammatory processes may contribute to pain.
The active ingredients work together by:
- Narrowing dilated blood vessels associated with migraine
- Reducing migraine-related vascular changes
- Enhancing the effectiveness of ergotamine through the addition of caffeine
Cafergot is generally most effective when taken early in a migraine attack, according to a healthcare provider’s instructions.
How Should Cafergot Be Taken?
Cafergot should always be taken exactly as prescribed.
General recommendations include:
- Use only when migraine symptoms begin.
- Follow the prescribed dosing instructions carefully.
- Do not exceed the recommended maximum dose.
- Avoid using the medication more frequently than recommended.
Using ergotamine-containing medications too often may lead to medication-overuse headaches or increase the risk of serious side effects.
Common Side Effects
Like all medications, Cafergot may cause side effects.
Common side effects include:
- Nausea
- Vomiting
- Dizziness
- Drowsiness
- Tingling sensations
- Weakness
- Muscle pain
- Nervousness related to caffeine
Many side effects are mild, but persistent or worsening symptoms should be discussed with a healthcare provider.
Serious Safety Warnings
Although uncommon, serious adverse effects can occur.
Potential serious risks include:
- Reduced blood flow to the hands, feet, or other parts of the body
- Chest pain
- Severe increases in blood pressure
- Heart attack or stroke in susceptible individuals
- Severe allergic reactions
- Medication-overuse headache with excessive use
Seek emergency medical attention immediately if you develop severe chest pain, sudden weakness, difficulty speaking, severe pain or numbness in the limbs, or signs of a severe allergic reaction.
Important Precautions
Before taking Cafergot, tell your healthcare provider if you have:
- Coronary artery disease
- Peripheral vascular disease
- High blood pressure
- Liver disease
- Kidney disease
- A history of stroke
- Pregnancy or plans to become pregnant
- Breastfeeding considerations
Cafergot should not be used during pregnancy because ergotamine can reduce blood flow to the uterus and may harm the developing fetus.
Drug Interactions
Cafergot has several clinically important drug interactions.
Tell your healthcare provider about all:
- Prescription medications
- Over-the-counter medicines
- Vitamins
- Herbal supplements
Particular caution is required with:
- Certain antibiotics
- Some antifungal medications
- HIV medications
- Other migraine medications, including certain triptans
- Medicines that strongly affect liver enzymes responsible for drug metabolism
These combinations can increase the risk of serious side effects.
Safe Storage
Store Cafergot according to the prescription label.
General recommendations include:
- Keep tablets in their original container.
- Store at room temperature.
- Protect from excessive heat, moisture, and light.
- Keep out of the reach of children and pets.
Do not use expired medication.
Frequently Asked Questions
What is Cafergot used for?
Cafergot is prescribed to treat migraine attacks after symptoms begin. It is not intended to prevent migraines.
Can Cafergot prevent migraines?
No. Cafergot is designed to treat acute migraine attacks rather than prevent them.
Why does Cafergot contain caffeine?
Caffeine helps improve the absorption and effectiveness of ergotamine, enhancing its ability to relieve migraine symptoms.
Can I use Cafergot for every headache?
No. Cafergot should only be used for the type of headache your healthcare provider has diagnosed, typically migraine. It is not appropriate for many other headache types.
Who should avoid Cafergot?
People with certain cardiovascular diseases, uncontrolled high blood pressure, significant liver or kidney disease, or those who are pregnant should generally avoid Cafergot unless specifically directed by a healthcare professional.
Conclusion
Cafergot 1 mg/100 mg is a prescription medication that combines ergotamine and caffeine to treat acute migraine attacks. When used appropriately and under medical supervision, it can be effective in relieving migraine symptoms for selected patients.
Because Cafergot carries important safety risks and interacts with many medications, it should be used only as prescribed. Patients should follow dosing instructions carefully, avoid exceeding recommended limits, and consult their healthcare provider if migraine attacks become more frequent or if concerning side effects occur.
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